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Information reprinted from the Juvéderm™ website. What Is Juvéderm™ Injectable Gel? As we age, our skin changes. Over time, the natural volume of youthful skin begins to diminish as wrinkles and folds form. But, with Juvéderm™ injectable gel, you don't have to just sit back and let it happen! Recently approved by the FDA, Juvéderm™ injectable gel is a “next-generation” dermal filler. The smooth consistency gel helps to instantly restore your skin's volume and smooth away facial wrinkles and folds, like your "smile lines" or “parentheses” (nasolabial folds—the creases that run from the bottom of your nose to the corners of your mouth). Juvéderm™ is a smooth consistency gel made of hyaluronic acid—a naturally occurring substance in your skin that helps to add volume and hydration. Your healthcare professional eases Juvéderm™ injectable gel under the skin to provide a smooth, natural look and feel—so everyone will notice (but no one will know)! In fact, studies show superior results of Juvéderm™ compared to a collagen-based dermal filler.* And, almost 90% of all study volunteers who were treated with both Juvéderm™ injectable gel and another dermal filler* preferred Juvéderm™! In addition, Juvéderm™ injectable gel is the first FDA-approved hyaluronic acid dermal filler that is proven to be safe and effective for persons of color. With Juvéderm™ the injection process takes only about 15 minutes and results are immediate. Plus, there's minimal recovery or downtime. So you can step into your doctor's office for treatment and step right back into your life. Join the Benefits Program to enjoy special offers, exclusive invitations, and more from the Allergan Medical family of products!

What is Juvéderm™?

Juvéderm™ injectable gel is a “next-generation” smooth consistency gel dermal filler that helps to instantly restore your skin's volume and smooth away facial wrinkles and folds like your “smile lines” or “parentheses” (nasolabial folds—the creases that run from the bottom of your nose to the corners of your mouth). Juvéderm™ comes in two formulations—Juvéderm™ Ultra and Juvéderm™ Ultra Plus.

What does Juvéderm™ do?

Juvéderm™ injectable gel temporarily adds volume to facial tissue and restores a smoother appearance to the face.

What is Juvéderm™ indicated for?

Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels are indicated for injection into the mid to deep dermis (below the outer layer of skin) for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds (the creases running from the bottom of your nose to the corners of your mouth).

Why does Juvéderm™ come in two formulations?

Juvéderm™ injectable gel is available in two formulations to allow your healthcare professional to tailor treatment to your unique needs. Juvéderm™ Ultra provides versatility in contouring and volumizing facial wrinkles and folds. Juvéderm™ Ultra Plus is a more robust formulation for volumizing and correcting deeper folds and wrinkles.

What makes Juvéderm™ different from other dermal fillers?

Juvéderm™ injectable gel employs its unique manufacturing process to provide the highest concentration of cross-linked hyaluronic acid of any currently available hyaluronic acid dermal filler for long-lasting results. This advanced manufacturing process works to create a smooth consistency gel that flows easily into the skin and provides a smooth, natural look and feel. All other currently approved hyaluronic acid dermal fillers are made of granular consistency gels. And, Juvéderm™ is the first hyaluronic acid dermal filler that has demonstrated its safety and effectiveness in persons of color.

How is Juvéderm™ injectable gel different from BOTOX® Cosmetic?

Juvéderm™ injectable gel is a “next generation” hyaluronic acid dermal filler that provides volume and is used to treat wrinkles and folds resulting from a loss of volume beneath the surface of the skin such as perioral lines and nasolabial folds (lines around your mouth and nose). Juvéderm™ restores your skin's volume for a smooth, natural look and feel. BOTOX® Cosmetic is not a filler. BOTOX® Cosmetic relaxes muscle activity and is used to treat moderate to severe lines caused by the dominant frown muscles between the eyebrows (the glabellar area). This allows the two vertical lines between the brows, often referred to as the “11,” to temporarily diminish for a smoother appearance. For important safety information about BOTOX® Cosmetic, see below.

What is hyaluronic acid?

Hyaluronic acid is a naturally occurring substance found in all mammals that helps to hydrate and add volume to your skin. In addition to its use as an aesthetic treatment, hyaluronic acid has also been used for more than 20 years for injection into arthritic joints to aid movement as well as for eye surgeries and wound repair.

What is cross-linked hyaluronic acid?

“Uncross-linked” hyaluronic acid in its natural form is in a liquid state. “Cross-linking” is the process through which hyaluronic acid is made into a gel product that can be injected into the skin for long-lasting results.

How is Juvéderm™ injectable gel used in treatment?

Your healthcare provider eases Juvéderm™ injectable gel into the skin using a fine needle to temporarily fill in and augment the treatment area and smooth moderate to severe facial wrinkles and folds such as “smile lines” or “parentheses” (nasolabial folds) and “marionette lines” (oral commissures). Juvéderm™ temporarily adds volume to the skin and may give the appearance of a smoother surface.

What will treatment with Juvéderm™ injectable gel accomplish?

Juvéderm™' injectable gel will help to smooth moderate to severe facial wrinkles and folds. Most patients need one treatment to achieve optimal wrinkle smoothing, and the results last about 6 months.

Is treatment with Juvéderm™ injectable gel painful?

Injections may cause some discomfort during and after the injection. Juvéderm™'s smooth consistency gel allows your doctor to administer it easily and smoothly. And, Juvéderm™ is injected directly into the skin using a fine needle to reduce injection discomfort. Your doctor may choose to numb (anesthetize) the treatment area to further minimize discomfort.

How long does treatment usually take?

The injection process takes only about 15 minutes. You'll also need to allow time to consult with your doctor prior to treatment.

What kind of doctor can provide treatment with Juvéderm™ injectable gel?

Any authorized healthcare professional can administer Juvéderm™ injectable gel, but dermatologists, plastic surgeons, ophthalmologists, otolaryngologists (ear, nose, and throat doctors), or physicians specializing in cosmetic procedures are generally more experienced.

Does the correction last forever?

No. Correction is temporary; therefore, touch-up injections as well as repeat injections are usually needed to maintain optimal corrections.

How long do results last?

Juvéderm™'s unique formulation provides results that last up to 6 months or longer.

What are the possible side effects of Juvéderm™ injectable gel?

Most side effects are mild or moderate in nature, and their duration is short lasting (7 days or less). The most common side effects include, but are not limited to, temporary injections site reactions such as: redness, pain/tenderness, firmness, swelling, lumps/bumps, bruising, itching, and discoloration. As with all skin injection procedures there is a risk of infection.

Can people with different skin tones/colors be treated with Juvéderm™?

Yes. In fact, Juvéderm™ injectable gel is the first FDA-approved hyaluronic acid dermal filler that has proven its safety and effectiveness in persons of color. Studies with Juvéderm™ showed no increased risk of hyperpigmentation or hypertrophic scarring in patients of color.

Juvéderm™ Ultra and Juvéderm™ Ultra Plus are indicated for injection into the mid to deep dermis for correction of moderate to severe facial wrinkles and folds (such as nasolabial folds). Side effects were usually mild to moderate lasting 7 days or less and included temporary injection site reactions like redness, pain, firmness, swelling and bumps.

Juvéderm™ injectable gel is available by Rx only.

Information reprinted from Allergan, manufacturer of Juvéderm™.

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